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Trends Biochem Sci. 1996 Jan;21(1):18-22.

The molecular control mechanisms of meiosis in fission yeast.

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Department of Biophysics and Biochemistry, School of Science, University of Tokyo, Japan.


Recent experiments have shown that the inactivation of a protein kinase, pat1, and the activation of an RNA-binding protein, mei2, commit fission yeast cells to enter meiosis. Both the cyclic AMP cascade and the mitogen-activated protein kinase cascade seem to be involved in this activation/inactivation. An RNA molecule that cooperates with mei2 to play a critical role in the promotion of meiosis I has also been identified.

[Indexed for MEDLINE]

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