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Neurosci Lett. 1996 Jan 5;202(3):161-4.

Overexpression of Bcl-2 in a murine dopaminergic neuronal cell line leads to neurite outgrowth.

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Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, USA.


A dopaminergic neuronal cell line was established which stably expressed human Bcl-2 (MN9D/Bcl-2) or a control vector (MN9D/Neo). Overexpression of Bcl-2 cells led to robust neurite formation without cessation of cell division. Most markers of neuronal and/or dopaminergic maturation were unchanged although the synaptosomal associated protein, SNAP-25, was increased three-fold in MN9D/Bcl-2 cell lines. These data support a role for Bcl-2 in developmental processes at least during a certain stage(s) of neurogenesis.

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