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Bull World Health Organ. 1995;73(5):659-65.

Genetic red cell disorders and severity of falciparum malaria in Myanmar.

Author information

1
Department of Medical Research, Ministry of Health, Yangon, Myanmar.

Abstract

A hospital-based survey was undertaken to investigate the relationship between the incidence and severity of malaria infection and various red cell disorders in Myanmar. The mean parasitaemia levels of patients with alpha- or beta-thalassaemia trait or with severe glucose-6-phosphate dehydrogenase (G6PD) deficiency were lower than those of individuals with normal haemoglobin AA or with heterozygous haemoglobin E. The double genetic defect of thalassaemia trait and severe G6PD deficiency appeared to confer some degree of protection against malaria.

PMID:
8846492
PMCID:
PMC2486814
[Indexed for MEDLINE]
Free PMC Article

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