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J Pediatr Hematol Oncol. 1996 May;18(2):191-4.

Acute renal failure with hyperuricemia as initial presentation of leukemia in children.

Author information

1
Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, USA.

Abstract

PURPOSE:

We report on two children who presented with hyperuricemia and acute renal failure (admission uric acid levels 57.4 and 59.2 mg/dl).

RESULTS:

Both were subsequently diagnosed to have acute lymphoblastic leukemia, despite normal initial complete blood counts and peripheral smear. Neither patient had nephromegaly on renal ultrasound.

CONCLUSIONS:

Hyperuricemia and acute renal failure, particularly if recurrent, may be an early presentation of childhood leukemia and should lead to a bone marrow aspirate/biopsy.

PMID:
8846137
[Indexed for MEDLINE]
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