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J Pediatr Hematol Oncol. 1996 May;18(2):122-9.

Osmotic scan ektacytometry in clinical diagnosis.

Author information

1
Department of Biochemistry, Wayne State University Medical School, Detroit, MI 48201, USA.

Abstract

PURPOSE:

The use of red blood cell deformability measurements in the diagnosis of hemolytic anemia is reviewed.

PATIENTS AND METHODS:

Results from 500 individuals are discussed. Erythrocytes were characterized by the automated measurement of cell deformability as the tonicity of the medium is varied (osmotic scan ektacytometry).

RESULTS:

The measurement yields a reliable identification of hemolytic anemias caused by deficiencies or abnormalities in erythrocyte structural proteins. In addition, it can, with good reliability, signal the presence of a glycolytic enzyme deficiency. The scan is complete in 15 min, and can therefore give a rapid indication of the type of hemolytic anemia. The osmotic scans of other hemolytic anemias are also discussed.

CONCLUSION:

The analysis of red blood cell deformability can offer a valuable addition to diagnostic methods in hemolytic anemia.

[Indexed for MEDLINE]

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