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Arthritis Rheum. 1996 Oct;39(10):1664-8.

Development of the anti-Ro autoantibody response in a patient with systemic lupus erythematosus.

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1
Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, USA.

Abstract

OBJECTIVE:

To characterize the initial events in anti-Ro production by a patient with systemic lupus erythematosus, in whom this autoantibody is developing.

METHODS:

The immune response to the Ro ribonucleoprotein and other autoantigens were studied by enzyme-linked immunosorbent assay for IgG and IgM, by isoelectric focusing, and by inhibition studies to determine apparent avidity.

RESULTS:

The patient's sera showed an oligoclonal response to Ro that increased in complexity and affinity with time. IgM anti-Ro appeared shortly before IgG anti-Ro, and disappeared as IgG anti-Ro increased in titer and affinity. IgG antiribosomal P autoantibodies also appeared during the patient's course, but in contrast to anti-Ro, were not preceded by IgM antiribosomal P.

CONCLUSION:

These data are consistent with the Ro autoantigen being presented and processed in a manner similar to heterologous antigen, and with differences in the mechanisms that lead to the production of IgG anti-Ro autoantibodies as opposed to antiribosomal P autoantibodies.

PMID:
8843856
DOI:
10.1002/art.1780391008
[Indexed for MEDLINE]

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