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Am J Physiol. 1996 Sep;271(3 Pt 1):C863-8.

Temperature modulation of calcium channel function in GH3 cells.

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  • 1Department of Neurology, School of Medicine, State University of New York, Stony Brook 11794-8121, USA.


The effect of temperature on calcium channel function was studied in GH3 cells, using the whole cell patch-clamp methodology. Specific parameters examined were peak current amplitude, activation time, and inactivation time. Over the temperature range studied (22-37 degree C), the peak current amplitude was found to be a non-linear function of temperature, with low-threshold currents more temperature dependent than high-threshold currents. Both activation time and inactivation time were faster at higher temperatures, but, whereas inactivation was a continuous function of temperature, activation was not, with a distinct discontinuity between 27 and 32 degrees C. These findings suggest that caution must be exercised in extrapolating data on channel function obtained at room temperature to physiological temperatures.

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