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Biomaterials. 1996 Aug;17(16):1631-7.

Prevention of prosthetic valve endocarditis by impregnation of gentamicin into surgical pledgets.

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Department of Chemistry, National University of Singapore, Kent Ridge, Singapore.


A novel drug delivery system was developed for the treatment of prosthetic valve endocarditis (PVE). The antibiotic, gentamicin, was impregnated into surgical pledgets using non-solvent coacervation of polylactic acid (PLA) as a binding/encapsulating agent. The in vitro dissolution profiles show controlled release of gentamicin for up to 36 h when PLA of molecular weight 2000 is used and up to 7 d for PLA with a molecular weight of 50,000. The results indicate potential for the localized treatment of PVE, which is cost-effective, easy to manufacture and permits dosage variability.

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