Format

Send to

Choose Destination
Immunol Res. 1996;15(2):151-62.

Murine natural killer cell differentiation: past, present, and future.

Author information

1
Laboratory of Molecular Pathology, University of Texas Southwestern Medical Center, Dallas 75235-9072, USA.

Abstract

Natural killer cells are bone marrow-derived lymphocytes capable of lysing a variety of target cells without prior exposure. While the biological activities and function of mature NK cells have been extensively investigated, the differentiation of NK cells from primitive hematopoietic stem cells is poorly understood. Recently, we have reported on the identification of a highly enriched bone marrow population capable of repopulating recipient mice with mature NK cells. In this review, we will summarize our findings and those of others in an attempt to clarify the current status of murine natural killer cell differentiation.

PMID:
8839783
DOI:
10.1007/bf02918504
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center