Format

Send to

Choose Destination
Spine (Phila Pa 1976). 1996 Jul 15;21(14):1653-5; discussion 1655-6.

Prostaglandin E2 content in herniated lumbar disc disease.

Author information

1
Mercy Hospital of Buffalo, New York, USA.

Abstract

STUDY DESIGN:

A prospective series of biochemical assays for prostaglandin E2 content in symptomatic herniated lumbar disc specimens.

OBJECTIVES:

To help clarify the pathogenesis of lumbar radiculopathy.

SUMMARY OF BACKGROUND DATA:

Three recent studies have shown elevated levels of prostaglandin E2 in intervertebral disc herniations. None of these studies correlated symptoms with prostaglandin E2 levels.

METHODS:

Twenty-four disrupted disc samples were purified by a standard solid phase extraction method and analyzed for prostaglandin E2 with an enzyme-linked immunosorbent assay. Clinical and anatomic correlations were sought with analysis of variance and t test.

RESULTS:

Sequestered discs tended to be associated with a higher prostaglandin E2 content than extruded discs, which in turn, tended to be associated with higher prostaglandin E2 content than protruded ones. A positive straight leg raising test appeared to be associated with a higher prostaglandin E2 content than a negative test.

CONCLUSIONS:

Prostaglandin E2 appears to mediate some of the inflammatory effects of lumbar disc herniation. An intact anulus may provide some protection against this stimulus.

PMID:
8839467
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center