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Eur J Pharmacol. 1996 Jan 25;296(2):R1-R3.

HmGlu1d, a novel splice variant of the human type I metabotropic glutamate receptor.

Author information

1
Preclinical Research, Sandoz Pharma AG, Basle, Switzerland.

Abstract

A novel splice variant, hmGlu1d, of the human mGlu1 metabotropic glutamate receptor has been isolated from a human brain library. This clone is identical to human mGlu1a except that it lacks 35 nucleotides in the 3' coding sequence, which predicts a truncated protein and a novel carboxy terminus. After injection of the encoding sequence into mouse A9 fibroblasts, quisqualate and (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid ((1S,3R)-ACPD) elicited concentration-dependent increases in intracellular Ca2+ (pEC50 values of 6.09 and 4.33, respectively).

PMID:
8838462
DOI:
10.1016/0014-2999(95)00868-3
[Indexed for MEDLINE]

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