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J Rheumatol. 1995 Dec;22(12):2246-9.

Skeletal muscle pathology in systemic sclerosis.

Author information

1
Anatomia Patológica, Instituto de Infectologia Emílio Ribas, São Paulo, Brazil.

Abstract

OBJECTIVE:

Systemic sclerosis (SSc) is characterized by abnormal deposition of collagen in the skin and by visceral involvement. Muscle weakness is a relatively frequent complication of SSc, although severity varies. We studied muscle pathology in patients with SSc with progressive muscle involvement.

METHODS:

We performed histochemical and immunohistochemical investigations to detect neural cell adhesion molecule (NCAM).

RESULTS:

Five of the 6 cases of SSc expressed NCAM in atrophic angulated fibers (some fibers stained heavily with oxidative enzymes).

CONCLUSION:

Neurogenic involvement in SSc is more frequent than reported.

PMID:
8835557
[Indexed for MEDLINE]

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