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Dermatology. 1996;192(2):94-8.

Expression of cyclin D1 and p53 protein in various malignant skin tumors.

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1
Department of Dermatology, Hyogo College of Medicine, Japan.

Abstract

BACKGROUND:

Overexpression of cyclin D1 and p53 protein has been reported in many types of malignant tumors.

OBJECTIVES:

We investigated whether cyclin D1 was detected immunohistochemically in various types of malignant tumors of the skin, comparable with p53 protein.

METHODS:

Immunohistochemical staining of cyclin D1 and p53 protein was applied to squamous cell carcinoma, malignant melanoma and malignant fibrous histiocytoma and various kinds of benign skin tumors.

RESULTS:

Cyclin D1 was positive only in malignant tumors at the same incidence as p53 protein.

CONCLUSION:

Cyclin D1 immunohistochemical staining may be a malignant marker for various skin tumors.

PMID:
8829518
DOI:
10.1159/000246329
[Indexed for MEDLINE]
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