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Trends Microbiol. 1996 Jul;4(7):290-3.

Immunological determinants of disease caused by respiratory syncytial virus.

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Dept of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-2605, USA.


Various disease syndromes caused by respiratory syncytial virus (RSV) may have a common mechanism of pathogenesis mediated by cytokines produced by type 2 T helper cells. The nature of the immune response to RSV is determined by the pattern of cytokines produced sequentially by many different cell types. Vaccination can influence the types of cytokine produced by selectively activating T cell subpopulations and inducing an immune response that clears the virus with minimal immunopathology.

[Indexed for MEDLINE]

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