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Trends Microbiol. 1996 Jul;4(7):270-4.

Hepatitis B virus-induced hepatocellular carcinoma: possible roles for HBx.

Author information

1
Dept of Biochemistry, McGill University, Montreal, Quebec, Canada. cromlish@medcor.mcgill.ca

Abstract

The hepatitis B virus-encoded protein, HBx, may contribute to carcinogenesis by perturbing cell growth and differentiation. There is some evidence indicating that HBx represses the nuclear import of the tumour repressor p53 and p53-dependent trans-activation and that HBx activates members of the basic region-leucine zipper (bZIP) family.

PMID:
8829335
[Indexed for MEDLINE]

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