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Trends Microbiol. 1996 Jul;4(7):264-9.

The murine coronavirus as a model of trafficking and assembly of viral proteins in neural tissue.

Author information

1
Dept of Microbiology and Immunology, University of Western Ontario, London, Canada.

Abstract

The replication of JHM, a murine coronavirus, provides a useful model of the assembly and dissemination of viral components in neuronal cells. Involvement of microtubules in virus trafficking is an important feature which may explain dissemination of the infection from primary cell targets at olfactory, hippocampal and cerebellar sites within the central nervous system, resulting in severe neuropathies.

PMID:
8829334
DOI:
10.1016/0966-842x(96)10045-7
[Indexed for MEDLINE]

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