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Vet Clin North Am Food Anim Pract. 1996 Jul;12(2):313-43.

Immunology: resistance to paratuberculosis.

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International Association for Paratuberculosis, Inc. Rehoboth, Massachusetts, USA.


Disease caused by Mycobacterium paratuberculosis involves a complex interaction of lymphoid and phagocytic cells of the peripheral and mucosal immune responses. For resistance to develop, animals must generate an effective cellular immune response to primary infections as well as multifocal exogenous and endogenous reinfections. If an effective immune response does not develop, infected animals transgress through a complex immunologic spectrum in which the immunologic reactions themselves are responsible for the disease manifestations.

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