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Microb Pathog. 1996 Jul;21(1):17-22.

Protection of mice against fatal pneumococcal challenge by immunization with pneumococcal surface adhesin A (PsaA).

Author information

1
Division of Bacterial and Mycotic Diseases, Center for Disease Control and Prevention, Atlanta, Georgia 30333, USA.

Abstract

Pneumococcal surface adhesin A (PsaA) is a 37-kDa surface protein present on Streptococcus pneumoniae having significant homology with fimbrial adhesion proteins. Immunization of CBA/CaHNJ Xid mice with PsaA using either complete Freund's or TiterMax adjuvants significantly protected mice against heterologous intravenous challenge with type 3 pneumococcal strain WU2 at doses up to 45 times the LD50. The results indicate that PsaA warrants further evaluation as a vaccine candidate for human pneumococcal disease.

PMID:
8827703
DOI:
10.1006/mpat.1996.0038
[Indexed for MEDLINE]

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