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Cancer. 1995 Apr 1;75(7):1619-26.

Benefit of mammography screening in women ages 40 to 49 years. Current evidence from randomized controlled trials.

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1
Department of Radiology, University of Colorado Health Sciences Center, Denver, USA.

Erratum in

  • Cancer 1995 Jun 1;75(11.

Abstract

BACKGROUND:

Eight randomized controlled trials (RCTs) of screening mammography were conducted involving women ages 40 to 49 years at entry. Current data gathered for periods ranging from 7 to 18 years of follow-up are available from these trials.

METHODS:

Meta-analyses were performed using a Mantel-Haenszel estimator method to combine current follow-up data from the eight RCTs of mammography that included women ages 40 to 49 years.

RESULTS:

Combining all current data on women ages 40 to 49 years at entry into the trials yielded a 16% [corrected] benefit from screening mammography, without statistical significance at the 95% confidence level. Combining all data on women ages 40 to 49 years at entry, excluding results from the Canadian National Breast Screening Study, yielded a 24% [corrected] benefit to women invited for screening, with statistical significance at the 95% confidence level.

CONCLUSIONS:

These results suggest that screening mammography in women ages 40 to 49 years at entry can reduce mortality from breast cancer when combined with adequate follow-up.

PMID:
8826919
[Indexed for MEDLINE]
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