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Trends Microbiol. 1996 Jan;4(1):5-9.

Epigenetic phase variation of the pap operon in Escherichia coli.

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1
Dept of Pathology, Health Sciences Center, Salt Lake City, UT 84132, USA.

Abstract

Expression of the pyelonephritis-associated pilus (pap) operon in Escherichia coli is regulated by a complex epigenetic phase-variation mechanism involving the formation of differential DNA-methylation patterns. This review discusses how DNA-methylation patterns are formed by protein-DNA interactions and how methylation patterns, in turn, control pap gene expression.

PMID:
8824788
[Indexed for MEDLINE]

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