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Trends Neurosci. 1996 Feb;19(2):62-8.

Cell division and the nervous system: regulating the cycle from neural differentiation to death.

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  • 1Dept of Neurology, University of Minnesota, Minneapolis 55455, USA.


It has long been recognized that the balance between cellular proliferation and cell death during embryogenesis is a key factor in formation of the CNS. The recent definition of molecular mechanisms that drive the cell-division cycle and programmed cell death provides an opportunity to investigate the molecular interactions that co-ordinate cell-cycle regulation with CNS-pattern formation, neural differentiation and histogenesis. It is proposed that not only is the cell-division cycle regulated by developmentally controlled molecular signals to halt or proceed, but gene products that drive the cycle can also influence the course of neural differentiation and apoptosis.

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