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Scand J Gastroenterol. 1996 Jul;31(7):665-70.

Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day.

Author information

1
Dept. of Medical Anatomy, Panum Institute, University of Copenhagen, Denmark.

Abstract

BACKGROUND:

The insulinotropic hormones gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), secreted from the K-cells of the upper small intestine and from the L-cells of the lower small intestine, respectively, are thought to be responsible for intestinal stimulation of insulin secretion. If true, their plasma concentrations should parallel the meal-related diurnal changes in plasma insulin concentrations.

METHODS:

Using COOH-terminal assays, thought to reflect accurately their rates of secretion, we measured circulating levels of GIP and GLP-1 in six normal subjects for 15 h of a day, during which they ate three mixed meals.

RESULTS:

Both GIP and GLP-1 concentrations increased significantly and in parallel with insulin in response to all three meals. The plasma insulin concentrations correlated significantly with both GIP and GLP-1 values throughout the study period (correlation coefficients, 0.49 +/- 0.07 and 0.56 +/- 0.05; p < 0.001).

CONCLUSIONS:

These results support the notion that GLP-1 and GIP are important incretin hormones.

PMID:
8819215
DOI:
10.3109/00365529609009147
[Indexed for MEDLINE]

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