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Protein Sci. 1996 Jul;5(7):1421-5.

The protein phosphatase 2C (PP2C) superfamily: detection of bacterial homologues.

Author information

1
European Molecular Biology Laboratory, Heidelberg, Germany. bork@embl-heidelberg.de

Abstract

A thorough sequence analysis of the various members of the eukaryotic protein serine/threonine phosphatase 2C (PP2C) family revealed the conservation of 11 motifs. These motifs could be identified in numerous other sequences, including fungal adenylate cyclases that are predicted to contain a functionally active PP2C domain, and a family of prokaryotic serine/threonine phosphatases including SpoIIE. Phylogenetic analysis of all the proteins indicates a widespread sequence family for which a considerable number of isoenzymes can be inferred.

PMID:
8819174
PMCID:
PMC2143460
DOI:
10.1002/pro.5560050720
[Indexed for MEDLINE]
Free PMC Article
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