Format

Send to

Choose Destination
Trends Biotechnol. 1996 Sep;14(9):335-41.

Generation of polyketide libraries via combinatorial biosynthesis.

Author information

1
Department of Chemical Engineering, Stanford University, Stanford 94305-5025, USA. ck@chemeng.stanford.edu

Abstract

Polyketides are a family of structurally complex natural products that include a number of important pharmaceuticals. Motivated by the value of these natural products, there has been much research focused on developing guidelines for engineering polyketide synthases (PKSs) to generate novel polyketides. Recent studies have provided interesting insights into the enzymatic specificity of the polyketide synthesis pathway, and have demonstrated that various PKSs can be genetically manipulated to synthesize 'unnatural' polyketide natural products. In this article, we discuss the synthesis of polyketides and polyketide libraries by combinatorial biosynthesis.

PMID:
8818287
DOI:
10.1016/0167-7799(96)10046-9
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center