Send to

Choose Destination
Mol Neurobiol. 1996 Apr;12(2):133-44.

Retinal ganglion cell dendritic development and its control. Filling the gaps.

Author information

Department of Developmental Neurobiology, UMDS, Guy's Hospital, London.


The way in which central neurons acquire their complex and precise dendrite arbors is of considerable developmental interest. Using retinal ganglion cells (RGCs) as a model, the mechanisms that pattern dendritic development are beginning to emerge. As in other systems, final dendrite phenotype is achieved by a mixture of intrinsic and extrinsic determinants. The extrinsic determinants of RGC dendrite shape reflect the anatomical constraints of producing a paracrystalline mosaic of arbors that laminates the inner plexiform layer of the retina. In this article, the key features of RGC dendrite development are reviewed. The emerging molecular mechanisms behind dendritic laminar segregation and "dendritic competition" are described. The role of afferent extrinsic influences are contrasted with those of retrograde, activity-dependent target influences that may regulate the final maturational phase of dendrite remodeling.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center