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Annu Rev Physiol. 1996;58:751-92.

Mutational analysis of motor proteins.

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Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia 19104-6085, USA.


Mutations in motor proteins, which can arise by design or randomly, provide powerful insights into the normal function of the protein. This review organizes the available data on mutations of members of the myosin, kinesin, and dynein superfamilies of motor proteins. These data contribute to an understanding of the cellular role of the motor proteins as well as provide insights into the fundamental mechanisms of motor function.

[Indexed for MEDLINE]

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