Send to

Choose Destination
Annu Rev Physiol. 1996;58:395-426.

Cyclic nucleotide-gated ion channels: an extended family with diverse functions.

Author information

Thomas C. Jenkins Department of Biophysics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.


An ion channel directly activated by cGMP was first discovered about ten years ago. Since then, a number of ion channels with the same property (cyclic nucleotide-activated channels) have been reported that are involved in a variety of cell functions. In addition, other channels have been found that are not primarily controlled by cyclic nucleotides but are modulated by them (cyclic nucleotide-modulated channels). These channels likewise have diverse functions and tissue distributions. Both channel classes are reviewed here. Coverage includes the cyclic-nucleotide binding site on these channels, ion permeation, pharmacological blockers, channel gating and modulation, and physiological functions of the channels.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center