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Mutat Res. 1996 Sep 2;364(1):1-11.

Reduced telomere length in ataxia-telangiectasia fibroblasts.

Author information

1
Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock 72205, USA.

Abstract

Chromosomal instability with a high frequency of telomere fusion is characteristic of ataxia-telangiectasia cells both in vivo and in vitro. We have measured telomere length and found it to be consistently reduced in both diploid and SV40-transformed cells A-T fibroblasts, relative to control cells. We examined a few possible mechanisms which might account for telomeric length reduction, including telomerase activity in transformed cells and endogenous nuclease activities, but found no differences between A-T and control cells in these parameters.

PMID:
8814333
DOI:
10.1016/0921-8777(96)00015-8
[Indexed for MEDLINE]

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