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Arthritis Rheum. 1996 Sep;39(9):1519-23.

Treatment of psoriatic arthritis with extracorporeal photochemotherapy and conventional psoralen-ultraviolet A irradiation.

Author information

1
Department of Dermatology, University Hospital, Linköping, Sweden.

Abstract

OBJECTIVE:

To study the use of combined photopheresis and psoralen-ultraviolet A irradiation (PUVA) in the treatment of psoriatic arthritis.

METHODS:

Eight patients with psoriasis and sero-negative arthritis received photopheresis for 12 weeks, followed by photopheresis plus PUVA for another 12 weeks. Clinical and laboratory examinations were performed every 3 months for up to 1 year after therapy.

RESULTS:

Four patients experienced a marked improvement of joint symptoms that lasted for > or = 12 months post-therapy (74% decrease in the Ritchie articular index; P < 0.01). Prior to therapy, these patients had a higher CD4:CD8 ratio than the poor responders. Only minor laboratory changes occurred.

CONCLUSION:

A more extensive trial of photopheresis plus PUVA in psoriatic arthritis is warranted.

PMID:
8814063
DOI:
10.1002/art.1780390911
[Indexed for MEDLINE]

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