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Mol Biochem Parasitol. 1996 Jun;78(1-2):47-54.

A homologue of the cysteine proteinase gene (ACP1 or Eh-CPp3) of pathogenic Entamoeba histolytica is present in non-pathogenic E. dispar strains.

Author information

1
Department of Membrane Research and Biophysics, Weizmann Institute of Science, Rehovot, Israel. bfmirelm@weizmann.weizmann.ac.il

Abstract

One of the three cysteine proteinase genes, ACP1 (or CP 3), has been reported to be missing in non-pathogenic strains of Entamoeba histolytica (or Entamoeba dispar as recently labeled). Unexpectedly, a gene fragment very similar in its sequence (95% homology) to ACP1 of pathogenic strains was obtained by use of the polymerase chain reaction from genomic DNA and cDNA of various cloned non-pathogenic strains as well as in 23 clinical isolates from asymptomatic carriers. The finding of the ACP1 homologue in non-pathogenic or E. dispar strains rules out the proposed use of its absence for diagnostic purposes.

PMID:
8813676
DOI:
10.1016/s0166-6851(96)02603-5
[Indexed for MEDLINE]

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