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Genomics. 1996 Aug 15;36(1):178-81.

Characteristics of the mouse genomic histamine H1 receptor gene.

Author information

1
Department of Molecular Immunology, Kyushu University 3-1-1, Higashi-ku, Fukuoka, 812, Japan.

Abstract

We report here the molecular cloning of a mouse histamine H1 receptor gene. The protein deduced from the nucleotide sequence is composed of 488 amino acid residues with characteristic properties of GTP binding protein-coupled receptors. Our results suggest that the mouse histamine H1 receptor gene is a single locus, and no related sequences were detected. Interspecific backcross analysis indicated that the mouse histamine H1 receptor gene (Hrh1) is located in the central region of mouse Chromosome 6 linked to microphthalmia (Mitfmi), ras-related fibrosarcoma oncogene 1 (Raf1), and ret proto-oncogene (Ret) in a region of homology with human chromosome 3p.

PMID:
8812432
DOI:
10.1006/geno.1996.0441
[Indexed for MEDLINE]
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