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Neurosci Biobehav Rev. 1996 Summer;20(2):183-8.

Modulation of insulin secretion by feeding behavior and physical activity: possible beneficial effects on obese and aged rats.

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Department of Physiology and Biophysics, São Paulo University, Brazil.


The high occurrence of diabetes in aged subjects is well known. In fact, the aging process is accompanied by obesity and presenting increased insulin release and lower peripheral responsiveness to this hormone. A recent study has shown that the changes in glucose utilization and insulin secretion during aging are abolished when obesity is somehow avoided. This fact justifies the effort to define new strategies to avoid the development of obesity during aging. In this review, beneficial effects of balanced diets, high frequency food intake and moderate exercise training on insulin secretion and its effect in rats are presented.

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