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Clin Exp Rheumatol. 1996 May-Jun;14(3):305-8.

Lack of correlation among the 3 outcomes describing SLE: disease activity, damage and quality of life.

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1
University of Toronto Lupus Clinic, Toronto Hospital, Ontario, Canada.

Abstract

OBJECTIVE:

The aim of the this study was to correlate three outcome measures in patients with SLE, namely disease activity, damage, and quality of life.

METHODS:

One hundred and five SLE patients completed the Medical Outcome Survey (MOS) SF-20 during their regular clinic visit. Disease activity (SLEDAI) and damage (SLICC/ACR Damage Index) were assessed according to a standard protocol. Statistical analyses included the Pearson correlation coefficients, a logistic regression, and a linear regression analysis.

RESULTS:

There was no correlation between the SLEDAI and SLICC/ACR DI. There was no correlation between the SLICC/ACR DI and any of the MOS domains by Pearson correlation. Although a statistical correlation was demonstrated between the SLEDAI score and the social functioning and health perception domains of the MOS SF-20, there were not clinically important.

CONCLUSION:

Thus, the three outcomes of disease activity, accumulated damage, and health status remain important independent outcome measures in the assessment of prognosis in patients with SLE.

PMID:
8809446
[Indexed for MEDLINE]

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