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Biochem J. 1996 Sep 1;318 ( Pt 2):459-62.

Cloning of a novel membrane-linked metalloproteinase from human myeloma cells.

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1
Department of Human Metabolism and Clinical Biochemistry, University of Sheffield Medical School, U.K.

Abstract

We have isolated a novel cDNA from human myeloma cells encoding a member of the reprolysin family of metalloproteinases. Derived amino acid sequence predicts a protein of approx. 76 kDa. The open reading frame predicts the presence of a leader peptide, a pro-peptide with a 'cysteine switch', a metalloproteinase domain, a disintegrin-like domain, a cysteine-rich domain, an epidermal growth factor-like domain and a putative transmembrane sequence. Expression of the mRNA for this metalloproteinase has been demonstrated in human myeloma cells.

PMID:
8809033
PMCID:
PMC1217643
[Indexed for MEDLINE]
Free PMC Article
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