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Muscle Nerve. 1996 Oct;19(10):1338-41.

Neuromyotonia and type I myofiber predominance in amyloidosis.

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Department of Neurology, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown 26506-9180, USA.


A case of amyloidosis presented with neurormyotonia and marked predominance of type I myofibers as documented by biopsy of an enlarged anterior tibialis muscle. This likely represents conversion of type II fibers to type I from continuous neuromyotonic stimulation. This transformation is well described to occur in animal models and this case represents a unique human example. Enlarged muscles likely reflected pseudohypertrophy.

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