Format

Send to

Choose Destination
Chem Biol. 1996 Jun;3(6):413-4.

Prion replication and secondary nucleation.

Author information

1
The Salk Institute for Biological Studies, P.O. Box 85800, San Diego, CA 92186-5800, USA.

Abstract

The infectious agents responsible for the prion diseases appear to be aggregates of a modified form of the prion protein, PrPSc, that grow at the expense of the normal form, PrPC. The mechanism of the transformation of PrPC to PrPSc is the subject of intense research interest. The way in which PrPSc aggregates generate new nuclei also deserves attention.

PMID:
8807870
DOI:
10.1016/s1074-5521(96)90087-3
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center