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Chem Biol. 1995 Dec;2(12):793-801.

Ribonucleotide reductases: radical enzymes with suicidal tendencies.

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Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, USA.


Ribonucleotide reductases catalyze a key step in DNA biosynthesis, using a diverse array of unprecedented metallo-cofactors to generate a transient protein radical that initiates nucleotide reduction. The new understanding of the chemistry and biochemistry of the system has allowed rational design of inhibitors of this process, which function as antitumor and antiviral agents.

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