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J Ethnopharmacol. 1996 Jul 26;53(1):11-4.

Antibacterial activity of the phenolic acids fractions of Scrophularia frutescens and Scrophularia sambucifolia.

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Laboratorio de Farmacognosia, Facultad de Farmacia, Universidad de Sevilla, Spain.


The phenolic fractions of aerial part of Scrophularia frutescens and S. sambucifolia (Scrophulariaceae) showed a potent antibacterial activity. Ferulic, isovanillic, p-hydroxycinnamic, p-hydroxybenzoic, syringic, caffeic, gentisic and protocatechuic acids were isolated from S. frutescens and ferulic, p-coumaric, vanillic, p-hydroxibenzoic and syringic acids were isolated from S. sambucifolia. Since phenolic acids have been shown in the literature to exert an antibacterial effect, the presence of these compounds in the two plants explains their antibacterial activity.

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