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Neurosci Lett. 1996 Jun 7;210(3):161-4.

Alterations in cortical thickness and neuronal density in the frontal cortex of Albert Einstein.

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  • 1Department of Neurology, University of Alabama at Birmingham 35294-0007, USA.


Neuronal density, neuron size, and the number of neurons under 1 mm2 of cerebral cortical surface area were measured in the right pre-frontal cortex of Albert Einstein and five elderly control subjects. Measurement of neuronal density used the optical dissector technique on celloidin-embedded cresyl violet-stained sections. The neurons counted provided a systematic random sample for the measurement of cell body cross-sectional area. Einstein's cortex did not differ from the control subjects in the number of neurons under 1 mm2 of cerebral cortex or in mean neuronal size. Because Einstein's cortex was thinner than the controls he had a greater neuronal density.

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