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Curr Opin Struct Biol. 1996 Jun;6(3):322-6.

Fluorescence studies of DNA and RNA structure and dynamics.

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Scripps Research Institute, Department of Molecular Biology, La Jolla, CA 92037, USA.


Fluorescence spectroscopy is increasingly being used as a technique for probing the structure and dynamics of nucleic acids. Recently, fluorescence methods have been used to elucidate the three-dimensional arrangement of complex DNA and RNA structures, characterize structural perturbations resulting from base bulges in helices and junctions, determine helical handedness in solution, and analyze the protein-induced melting of DNA.

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