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Curr Opin Struct Biol. 1996 Jun;6(3):395-401.

The RING finger domain: a recent example of a sequence-structure family.

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Department of Biochemistry, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.


In the past 18 months, two RING finger structures have been solved. They represent the first reported structures for this novel zinc-binding sequence motif. Both structures are significantly different from other zinc-binding domains, in terms of both their zinc-ligation scheme and their three-dimensional structures. The RING finger domain appears to be a convenient scaffold which can be altered to provide functional specificity in those proteins that contain the motif.

[Indexed for MEDLINE]

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