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FEBS Lett. 1996 Sep 9;393(1):53-6.

IL4 and IL13 receptors share the gamma c chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells.

Author information

1
INSERM U131, Institut Paris-Sud sur les Cytokines, Clamart, France.

Abstract

IL13 induces the same biological effects as IL4 in normal human B cells. We show that as in the IL4R complex, both IL4R alpha and IL2R gamma c are components of the IL13R and that both cytokines induced STAT6, STAT3 and STAT5 activation in B cells. In spite of this similar downstream signalling, IL4 and IL13 used a different set of Janus kinases: IL13 is unable to activate JAK1 and JAK3.

PMID:
8804422
DOI:
10.1016/0014-5793(96)00835-6
[Indexed for MEDLINE]
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