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J Med Vet Mycol. 1996 Jun-Jul;34(3):223-5.

Amphotericin B resistant isolates of Cryptococcus neoformans without alteration in sterol biosynthesis.

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Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, UK.


Amphotericin B resistant mutants of Cryptococcus neoformans were isolated accumulating mainly ergosterol. Cross-resistance to azole antifungals was not observed. Together with previous data this indicates that at least three categories of amphotericin B resistance can arise: sterol mutants, amphotericin B and azole cross-resistant mutants and amphotericin B resistant mutants with no azole cross-resistance.

[Indexed for MEDLINE]

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