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Trends Microbiol. 1995 Dec;3(12):463-8.

Bacterial superantigens in human disease: structure, function and diversity.

Author information

1
Department of Immunology and Molecular Biology, Army Medical Research Institute of Infectious Disease, Frederick, Maryland, USA.

Abstract

All bacterial superantigens use common structural strategies to bind to major histocompatibility complex class II receptors, while binding the T cell antigen receptor in different ways. Overstimulation of the immune response is responsible for the acute pathological effects, while reactivation of developmentally silenced T cells might result in autoimmune disease. Certain diseases might be controlled with superantigens or genetically attenuated vaccines.

PMID:
8800837
DOI:
10.1016/s0966-842x(00)89011-3
[Indexed for MEDLINE]

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