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FEBS Lett. 1996 Apr 8;384(1):31-4.

Degradation of glutathione S-conjugates by a carboxypeptidase in the plant vacuole.

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Fraunhofer Institut für atmosphärische Umweltforschung, Garmisch-Partenkirchen, Germany.


For plants, glutathione conjugation is a major pathway to detoxify organic xenobiotic. Glutathione S-conjugates (SG-conjugates) are formed in the cytosol, the in vitro transport over the tonoplast has been described and a final storage in the vacuole has been postulated. We show here that alachlor rapidly accumulates as GS-conjugates in the plant vacuole and that the first step of its degradation, the formation of the respective gamma-glutamylcysteinyl-S-conjugate, is catalyzed by a vacuolar carboxypeptidase. These results suggest the glutathione conjugate as a transport form but not a storage form of xenobiotic molecules.

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