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Mol Med Today. 1996 Jul;2(7):282-9.

The autoimmune basis of adrenocortical destruction in Addison's disease.

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1
Department of Internal Medicine, University Hospital, Uppsala University, Sweden. ola.winqvist@medicin.uu.se

Abstract

Addison's disease is mainly caused by autoimmune destruction of the steroid-producing cells in the adrenal glands. Key enzymes in steroid biosynthesis have been implicated as the major targets of autoantibodies in this disease. The study of B-cell-dependent autoimmune responses reveals two distinguishable forms of Addison's disease. This should permit very accurate diagnosis of the disease and increase future prospects of disease prevention.

PMID:
8796908
[Indexed for MEDLINE]
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