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Altern Ther Health Med. 1996 Mar;2(2):59-64.

A critique of the double-blind clinical trial. Part 2.

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Kritik der klinischen Doppelblindstudie, Munich, Germany.


The randomized, double-blind study is generally regarded as the gold standard of clinical drug trials. Bias can occur as a result of the blinding procedure itself, but discussions of this type of bias have been few and far between. This article continues with a detailed discussion of such blinding errors, which can obscure genuine drug effects and be of a sufficient magnitude as to generate false-negative results. Uncritical blinding in clinical studies should therefore be questioned.

[Indexed for MEDLINE]

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