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Psychol Aging. 1996 Jun;11(2):373-6.

Number of trials needed to assess human eyeblink classical conditioning.

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Department of Psychology, Temple University, Philadelphia, Pennsylvania 19122, USA.


Eyeblink classical conditioning (EBCC) is a useful paradigm for studying the neurobiology of learning and memory. EBCC shows large age effects and has been shown to be sensitive to Alzheimer-like neuropathology. The EBCC data of 241 participants, including young, middle-aged, and elderly normal adults, adults with Down's syndrome, and patients with probable Alzheimer's disease, were analyzed to identify a minimum number of trials for reliable assessment. Results indicate that EBCC performance can be as reliably assessed in 63 trials as in 90 trials. Using fewer conditioning trials reduces administration time, making EBCC more practical for both research and potential diagnostic purposes.

[Indexed for MEDLINE]

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