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Curr Opin Struct Biol. 1996 Aug;6(4):485-90.

Porins: general to specific, native to engineered passive pores.

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Institut für Organische Chemie und Biochemie, Albert-Ludwigs-Univerśität, Albertstrasse 21, D-79104, Freiburg im Breisgau, Germany.


Several porins from bacterial outer membranes have been crystallized and analyzed by X-ray diffraction, yielding a consistent picture of these membrane-channel proteins. The structures of general and specific channels are in agreement with electrophysiological, diffusional and biochemical data, and provide a starting point for the engineering of other passive membrane pores or porins with new selectivities.

[Indexed for MEDLINE]

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