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Curr Opin Neurobiol. 1996 Aug;6(4):533-41.

Cell fate specification in the inner ear.

Author information

1
Department of Biology, 140 Commonwealth Avenue, Chestnut Hill, Boston College, Massachusetts 02167, USA. feketed@bc.edu

Abstract

From its origin as a single ectodermal patch, the inner ear becomes a labyrinth of chambers housing six to eight sensory organs. Along the way, specific cell fates are realized. The secrets underlying these cell fate specifications are beginning to be revealed through the application of several molecular-genetic approaches. Recent papers describing such approaches have included gene expression studies in the early otic epithelium and inner ear sensory epithelia. large-scale screens of zebrafish mutants to identify ear defects, and targeted gene perturbations of neurotrophins. of their receptors or of the Brn-3.1 transcription factor in mice.

PMID:
8794105
DOI:
10.1016/s0959-4388(96)80061-4
[Indexed for MEDLINE]

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